Transcription and Neurodegeneration lab
PI: Snehajyoti Chatterjee
The Chatterjee Lab is part of the Department of Neuroscience and Pharmacology at the University of Iowa and part of the Iowa Neuroscience Institute. The primary focus of our lab is to understand the molecular mechanisms underlying long-term memory impairments in Alzheimer’s disease and related dementia (ADRD). We are particularly interested in understanding the role of transcription and the epigenetic machinery in this process.
In our laboratory, we use multifaceted state-of-the-art approaches such as single-nuclei (RNA+ATAC) multi-omics, spatial transcriptomics, native chromatin enrichment studies, proximity labeling, pharmacology, behavioral techniques, and AAV-based manipulation of transcription and epigenetic machinery in the mouse brain. Using these tools, our goal is to understand the molecular mechanisms that goes awry in neurodegeneration.
Our research covers several important projects. 1) To study the molecular mechanisms that cause long-term memory impairment in early- and late-onset mouse models of Alzheimer’s disease and related dementias. 2) Investigate the role of histone acylation modifications in memory and their impact on neurodegenerative diseases. 3) Delineate the molecular signature of memory and neuronal activation in mice and human brains using single-nuclei multi-omics and spatial transcriptomics approaches. 4) Understand how environmental toxins impact cognition and neurodegeneration in ADRD.
We are committed to advancing our understanding of the brain and finding new ways to address neurodegenerative diseases.
Funding Agency's
Graduate Program Affiliations
Center, Program and Institute Affiliations
